I prescribe Z3 and ME all the time, but not in the same session.
A typical Z3 aerobic workout will be more of a global stress, measured by heart rate, and done without extra weight.
ME will be more local to the muscles being worked, and the actual intensity covers a wide range. It could be Z3 in the legs but Z1/2 by heart rate for something like heavy uphill carries. Or both HR and local fatigue could be high if it’s a heavy jumping session.