This is a tricky one. The Big Vert has proven itself in single push events like the Tor d’Geant and Tor d’Glacier which are roughly 200 and 300 miles with no prolonged stops. I’m not sure if you listened to the pod cast I did with Luke Nelson but in the 6month leading up to his 7th place finish in Tor d’Geant his averaged weekly miles as 48. He had only a couple of weeks above 100miles. The ME seems to lessen the need for mega miles and mega vert running. We’ve seen this with hundreds of users. Are you still doing the optional ME progression? If so keep it up. That’ll make your legs more fatigue resistant. It won’t make you faster but it will keep you from slowing down so much.
In short I think you’ll be fine with the 100 miles you are calling your event and sticking to the prescribed distances and vert…..if you stick with the ME.